Opportunity Information: Apply for HRSA 22 086

The Autism Single Investigator Innovation Program (Autism-SIIP) - Autism Longitudinal Data Project (ALDP) is a discretionary federal funding opportunity from the U.S. Department of Health and Human Services (HHS), administered by the Health Resources and Services Administration (HRSA). It is offered as a cooperative agreement, meaning the recipient would typically carry out the project with substantial involvement from the federal agency compared with a standard grant. The opportunity is cataloged under CFDA 93.877 and was created on January 4, 2022, with an original application deadline of April 4, 2022.

The purpose of HRSA-22-086 is to support the implementation and completion of research that uses existing longitudinal data resources to deepen understanding of autism spectrum disorder (ASD) and developmental disabilities (DD), including common co-occurring conditions. Rather than funding the creation of entirely new cohorts or primary data collection as the centerpiece, the program emphasizes leveraging already-established longitudinal datasets and applying observational research methods and secondary data analyses. A major focus is evaluating the effects of early interventions using non-randomized designs appropriate for real-world data, with the broader goal of clarifying early life origins, early signs and indicators, developmental pathways, and intervention impacts for ASD/DD across childhood and beyond.

HRSA indicates that funded work should align with priorities of its Maternal and Child Health Bureau (MCHB). Applicants are expected to build on the current knowledge base by conducting analyses that extract additional value from longitudinal records, especially those that can illuminate how early biological and environmental factors relate to later outcomes. Key research areas include studying genetic and environmental, maternal and perinatal factors that may contribute to or predict ASD/DD; examining physical and behavioral trajectories over time and how assessment and presentation may differ across stages of development; and exploring the potential for primary prevention approaches, which can include identifying modifiable risk factors and protective factors that inform upstream public health or clinical strategies.

Another central component is studying the effects of ASD/DD interventions using observational studies and secondary data. This includes analyzing intervention exposure, timing, intensity, and real-world implementation as captured in existing datasets, and assessing how these relate to outcomes over time. Because the program is grounded in longitudinal resources, it implicitly supports work that can address questions about long-term impact, heterogeneity of response, and differences by population subgroups, service settings, or comorbidity profiles, as long as those analyses are feasible within the available data.

Beyond producing research findings, the ALDP also places value on dissemination and public impact. Applicants are expected to promote greater national and public awareness of early life origins, early indicators, and interventions for ASD/DD and associated comorbidities. This includes providing leadership in communicating results from ALDP-supported research, which can involve translating findings for broader audiences, sharing implications for maternal and child health systems, and helping inform practice, policy, and future research priorities.

Eligible applicants span a wide range of entities, including state, county, city/township, and special district governments; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; and nonprofit organizations with 501(c)(3) status (excluding institutions of higher education). The listing also includes an "Others" category with additional eligibility clarification referenced in the original notice. The funding opportunity anticipated a single award, with an award ceiling of $500,000, indicating a competitive, targeted investment aimed at supporting one strong, high-impact project that can quickly advance knowledge by making rigorous use of existing longitudinal data.

  • The Department of Health and Human Services, Health Resources and Services Administration in the health sector is offering a public funding opportunity titled "Autism Single Investigator Innovation Program (Autism-SIIP) – Autism Longitudinal Data Project (ALDP)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.877.
  • This funding opportunity was created on Jan 04, 2022.
  • Applicants must submit their applications by Apr 04, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $500,000.00 in funding.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for HRSA 22 086

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