Opportunity Information: Apply for 80JSC017N0001 FLAGSHIP1
Appendix A: NASA Research and Technology Development to Support Crew Health and Performance in Space Exploration Missions is a NASA Research Announcement (NRA) issued by the NASA Johnson Space Center under the Human Research Program (HRP). It sits as Appendix A within the broader Human Exploration Research Opportunities (HERO) NRA (solicitation number 80JSC017N0001), and it focuses on applied research that directly supports HRP goals and objectives tied to keeping astronauts healthy and performing well during space exploration missions. The specific response area highlighted in this appendix is “Space Radiobiology Tissue Sharing Research,” with an emphasis on projects that propose using existing (archived) tissue samples or tissue samples coming from ongoing experiments rather than generating entirely new sample collections.
The opportunity is structured to encourage researchers to extract additional scientific value from biological materials that NASA and partners have already collected, particularly for radiobiology questions relevant to spaceflight. In practice, this means proposals are expected to leverage tissue resources to investigate how space-relevant radiation affects biological systems, potentially improving understanding of health risks and informing countermeasures for long-duration missions. Because it is framed as applied research, NASA is generally looking for work that connects clearly to operational human spaceflight needs, such as risk reduction, evidence building for standards, or technology and methods that can improve risk characterization or mitigation.
NASA indicates multiple possible funding instruments may be used, including grants, cooperative agreements, and procurement contracts. The total funding per award is relatively modest, with an award ceiling listed at $200,000, and NASA anticipated making about four awards under this appendix at the time of posting. The program is categorized under Science and Technology and other Research and Development, and it is associated with CFDA number 43.003.
Eligibility is broad across U.S. institutions, meaning essentially any category of U.S.-based organization can apply (universities, companies, nonprofits, and government-affiliated labs, among others), subject to any additional constraints spelled out in the full solicitation. Principal Investigators are also allowed to collaborate widely, including with universities, federal laboratories, private sector partners, and state or local government labs. A key administrative point is that the submitting (lead) organization remains responsible for managing and administering the project in line with the management plan described in its proposal. NASA also notes that collaborations with non-U.S. organizations are possible only on a cooperative, no-exchange-of-funds basis, which typically means international partners can participate but NASA will not transfer grant funds to them.
The solicitation used a two-step proposal process. A virtual pre-proposers conference was scheduled for August 7, 2017 to help potential applicants understand the requirements and expectations. Step-1 proposals for Appendix A were due September 5, 2017, and only applicants invited after Step 1 were able to submit Step-2 proposals, which were due November 28, 2017. Supporting documents and full appendix details were provided through NASA’s HERO pages and the NSPIRES system, which is NASA’s platform for proposal submission and solicitation management.Apply for 80JSC017N0001 FLAGSHIP1
- The National Aeronautics and Space Administration, NASA Johnson Space Center in the science and technology and other research and development sector is offering a public funding opportunity titled "Appendix A: NASA Research and Technology Development to Support Crew Health and Performance in Space Exploration Missions" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 43.003.
- This funding opportunity was created on Aug 02, 2017.
- Applicants must submit their applications by Sep 05, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is Appendix A in this NASA opportunity?
Appendix A, titled "NASA Research and Technology Development to Support Crew Health and Performance in Space Exploration Missions," is a NASA Research Announcement (NRA) issued by the NASA Johnson Space Center under the Human Research Program (HRP). It is one appendix within the broader Human Exploration Research Opportunities (HERO) NRA (solicitation number 80JSC017N0001).
What is the main purpose of this Appendix A research area?
The focus is applied research that directly supports HRP goals and objectives related to keeping astronauts healthy and able to perform well during space exploration missions. NASA is looking for work that clearly connects to operational human spaceflight needs such as risk reduction, evidence building for standards, or methods/technologies that improve risk characterization or mitigation.
What specific response area is highlighted in this appendix?
The specific response area highlighted is "Space Radiobiology Tissue Sharing Research."
What does "Space Radiobiology Tissue Sharing Research" emphasize?
It emphasizes projects that use existing (archived) tissue samples or tissue samples coming from ongoing experiments, rather than generating entirely new sample collections.
Does this opportunity support creating new tissue sample collections?
Based on the emphasis described, proposals are expected to prioritize existing archived tissue resources or tissues from ongoing experiments rather than creating entirely new collections.
Why is NASA emphasizing the use of archived or ongoing-experiment tissues?
The appendix is structured to encourage researchers to extract additional scientific value from biological materials that NASA and partners have already collected, especially for radiobiology questions relevant to spaceflight.
What kinds of research questions are relevant under this appendix?
Research is expected to investigate how space-relevant radiation affects biological systems, with the goal of improving understanding of health risks and informing countermeasures for long-duration missions.
Is this basic research or applied research?
It is framed as applied research, meaning NASA generally expects proposals to show a clear line of relevance to operational human spaceflight needs and HRP objectives.
Which NASA program is associated with this appendix?
This appendix is issued under the Human Research Program (HRP) and is part of the broader Human Exploration Research Opportunities (HERO) NRA.
Who issued this NASA Research Announcement?
The NRA was issued by NASA Johnson Space Center.
What is the solicitation number for the broader HERO NRA?
The solicitation number is 80JSC017N0001.
What funding instruments might NASA use for awards?
NASA indicated multiple possible funding instruments, including grants, cooperative agreements, and procurement contracts.
What is the maximum funding amount per award under this appendix?
The award ceiling listed is $200,000 per award.
How many awards did NASA anticipate making under this appendix?
NASA anticipated making about four awards under this appendix at the time of posting.
What is the program category for this opportunity?
The program is categorized under Science and Technology and other Research and Development.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA number 43.003.
Who is eligible to apply?
Eligibility is broad across U.S. institutions. This includes essentially any category of U.S.-based organization (such as universities, companies, nonprofits, and government-affiliated laboratories), subject to any additional constraints in the full solicitation.
Are collaborations allowed, and with what types of partners?
Yes. Principal Investigators are allowed to collaborate widely, including with universities, federal laboratories, private sector partners, and state or local government laboratories.
Can non-U.S. organizations participate as collaborators?
Collaborations with non-U.S. organizations are possible only on a cooperative, no-exchange-of-funds basis. In practice, that means international partners may participate, but NASA will not transfer grant funds to them.
Which organization is responsible for administering the project?
The submitting (lead) organization remains responsible for managing and administering the project in line with the management plan described in its proposal.
Was there a pre-proposers conference?
Yes. A virtual pre-proposers conference was scheduled for August 7, 2017 to help potential applicants understand requirements and expectations.
What was the proposal submission process?
The solicitation used a two-step proposal process. Applicants first submitted Step-1 proposals, and only those invited after Step 1 were eligible to submit Step-2 proposals.
When were Step-1 proposals due for Appendix A?
Step-1 proposals for Appendix A were due September 5, 2017.
When were Step-2 proposals due?
Step-2 proposals were due November 28, 2017, and only invited applicants from Step 1 could submit them.
Where were the full details and supporting documents made available?
Supporting documents and full appendix details were provided through NASA's HERO pages and the NSPIRES system.
What is NSPIRES in the context of this opportunity?
NSPIRES is NASA's platform for solicitation management and proposal submission.
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